Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China

Iodine deficiency during pregnancy is a widespread public health concern, but indicators and methods for assessing iodine nutritional status are lacking. Serum concentration (SIC) an important metabolism biomarker can, to some extent, predict the risk of thyroid diseases, making it potential individual nutrition levels. Our study aimed analyze relationship between SIC function in cohort mild deficient pregnant women China order explore as pregnancy. A total 1540 early (gestation < 10 weeks) aged 18 45 years old were included final from Zhejiang multicenter population-based mother child cohort. Repeated measures SIC, urinary (UIC), taken at approximately 10, 17, 32 weeks gestation. The was statistically correlated with all indexes first trimester, very strong positive correlation FT4 over three trimesters (r = 0.449, 0.550, 0.544, respectively). Pregnant 72.4 µg/L higher hypothyroxinemia (adjusted OR 8.911, 95% CI 5.141–15.447) 1.244, 1.031–1.502), while those > 93.9 thyrotoxicosis 11.064, 6.324–19.357) excessive 6.324–19.357). In contrast, UIC not diseases (p 0.05). These findings indicate that dysfunction women.